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Journal · Biological age

What “biological age”
actually means

Your birthday counts years. Biological age tries to estimate how your body is aging at a cellular level — often using patterns in DNA methylation or other molecular signals. It’s a research idea that’s moved into consumer reports, not a second passport number.

The simple version

Different clocks and labs use different tissues, algorithms, and reference groups. Two reports can disagree and still both be “valid” in their own framing. Treat the number as a starting point for understanding, not a verdict.

What it’s useful for

Our job at cells.com is to help you interpret a result you already have — or point you to reputable third-party tests if you’re starting from zero — then turn that into a clear educational action plan. We don’t run the test or act as your clinician.

What this is not. Education only. Biological age estimates are not medical diagnoses. They do not replace care from a qualified clinician. cells.com does not diagnose, treat, prescribe, run laboratory tests, or ship kits. Nothing here is medical advice.

How this shows up on cells.com

If you already have a TruAge, Elysium, GlycanAge, or similar result, you’ll be able to bring it to cells.com for plain-language interpretation. If you don’t, we’ll help you understand what a first test is — without pretending we’re the lab.

References

  1. Horvath S. DNA methylation age of human tissues and cell types. Genome Biology. 2013;14(10):R115. doi:10.1186/gb-2013-14-10-r115
  2. Hannum G, Guinney J, Zhao L, et al. Genome-wide methylation profiles reveal quantitative views of human aging rates. Molecular Cell. 2013;49(2):359–367. doi:10.1016/j.molcel.2012.10.016
  3. Lu AT, Quach A, Wilson JG, et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging (Albany NY). 2019;11(2):303–327. doi:10.18632/aging.101684
  4. Belsky DW, Caspi A, Corcoran DL, et al. DunedinPACE, a DNA methylation biomarker of the pace of aging. eLife. 2022;11:e73420. doi:10.7554/eLife.73420
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Simon Ng is the founder of cells.com. He has spent more than a decade on biotech finance executive teams, including at Quark Pharmaceuticals and Adverum Biosciences, and holds an MBA.